牛磺罗定

资料来源：国家癌症研究所网站（http://www.cancer.gov）

具有抗菌，抗凝血和潜在抗血管生成活性的合成广谱抗生素......此外，牛磺酸还通过诱导各种凋亡因子促进细胞凋亡，并抑制血管内皮生长因子（VEGF）的产生，血管内皮生长因子是一种在血管生成中起重要作用的蛋白质。

这项研究表明：在目前的研究中，我们首次提出了TRD [Taurolidine]通过激活不同神经母细胞瘤细胞系内在和外在途径显着诱导细胞凋亡的详细证据。 TRD与细胞毒性药物多柔比星和长春新碱合作，目前用于神经母细胞瘤的治疗方案，使TRD成为治疗这种恶性和抗拒的儿童疾病的有希望的新候选者。

该研究得出结论：牛磺酸是具有肿瘤选择性细胞毒性的新型氧化还原导向的广谱抗肿瘤剂的代表。它通过靶向在许多肿瘤细胞中受损的氧化应激反应途径诱导程序性细胞死亡。在外科肿瘤学的最初应用中，Taurolidine i.v.基本上没有明显的副作用，值得进一步的临床评估。围手术期应用Taurolidine有望减少循环肿瘤细胞，这是无病生存的负面预测因子。

该研究得出结论：应用牛磺酸可以预防肺转移的发生。此外，在该体内模型中，牛磺酸似乎减少了确定的肺转移。 Taurolidine可为结肠腺癌患者提供额外的治疗选择。

Source: The website of the National Cancer Institute (http://www.cancer.gov)

A synthetic broad-spectrum antibiotic with antibacterial, anticoagulant and potential antiangiogenic activities… In addition, taurolidine also promotes apoptosis by inducing various apoptotic factors and suppresses the production of vascular endothelial growth factor (VEGF), a protein that plays an important role in angiogenesis.

This study says: In the current study we, for the first time, present detailed evidence that TRD [Taurolidine] significantly induces apoptosis via activating the intrinsic and extrinsic pathways in different neuroblastoma cell lines. TRD cooperates with the cytotoxic drugs doxorubicin and vincristine that are currently used in therapy regimens for neuroblastoma making TRD a promising novel candidate for treatment of this malicious and defying childhood disease.

This study concluded: Taurolidine is a representative of a novel class of redox-directed, broad-spectrum antineoplastic agents with tumor-selective cytotoxicity. It induces programmed cell death by targeting the oxidative stress response pathway which is compromised in many tumor cells. In initial applications in surgical oncology, Taurolidine i.v. was largely free of significant side-effects and merits further clinical evaluation. Applied perioperatively, Taurolidine promises to reduce circulating tumor cells, a negative predictor for disease-free survival.

This study concluded: The application of taurolidine tends to prevent the development of lung metastases. Furthermore, taurolidine seems to reduce established lung metastases in this in vivo model. Taurolidine may offer additional therapeutic options in patients with colon adenocarcinoma.