Description
This is a combination drug of an angiotensin receptor blocker (ARB), a calcium channel blocker and thiazide diuretic; the ARB inhibits vasoconstriction caused by angiotensin II in vascular smooth muscle to lower blood pressure, the calcium blocker decreases Ca2+sup/supinflow into the cell and relaxes the vascular smooth muscle to lower blood pressure, and the diuretic increases urine output via inhibition of sodium and water reabsorption in the kidney to lower blood pressure.
It is usually used to treat hypertension.
Presentation
100 tablets
Feature
pale orange tablet, diameter: approx. 11 mm, thickness: approx. 4.9 mm
Active Ingredients
Telmisartan
Amlodipine besilate
Hydrochlorothiazide
Effect/Efficacy
This is a combination drug of an angiotensin receptor blocker (ARB), a calcium channel blocker and thiazide diuretic; the ARB inhibits vasoconstriction caused by angiotensin II in vascular smooth muscle to lower blood pressure, the calcium blocker decreases Ca2+sup/supinflow into the cell and relaxes the vascular smooth muscle to lower blood pressure, and the diuretic increases urine output via inhibition of sodium and water reabsorption in the kidney to lower blood pressure.
It is usually used to treat hypertension.
Usage/Dosage
In general, for adults, take 1 tablet, once daily. Strictly follow the instructions.
To avoid possible effects of food, always take the drug at regular dosing schedule, that is, before every meal or after every meal.
If you miss a dose, skip the missed dose and follow your regular dosing schedule. You should never take two doses at one time.
If you accidentally take more than your prescribed dose, you may feel dizzy due to hypotension. Consult with your doctor or pharmacist immediately.
Do not stop taking this medicine unless your doctor instructs you to do so.
Cautions
If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have hepatic disorder, anuria, acute renal failure, reduction of sodium/potassium in body fluid or diabetes mellitus.
If you are on dialysis.
If you are pregnant, possibly pregnant or breastfeeding.
If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
The medicine may cause a decrease in blood pressure, dizziness and light headedness. Pay close attention when you work at heights or perform dangerous operations such as driving a car.
Pay attention that alcohol enhances postural hypotension (dizziness on standing up).
Avoid taking grapefruit juice with this medicine, since it may intensify the effects of this medicine.
Keep out of reach of children. Store away from direct sunlight, heat and moisture. Store in a light shielding condition after opening a package.
Discard the remainder. Do not store them. Seek advice of your pharmacy or medical institution about proper disposal of the unused medicines.
Contraindication
The most commonly reported adverse reactions include hypotension, postural hypotension (dizziness on standing up), vasculitis, facial flush, respiratory distress, gum hypertrophy, eczema, rash, itchiness, hives, erythema, erythema multiform and solar sensitiveness. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
swelling of eyelids/lips/tongue/throat, respiratory distress, blood pressure falling [angioedema]
numbness of the hands and lips, muscle weakness, paralysis of limbs [hyperkalaemia]
loss of appetite, nausea/vomiting, convulsion [hyponatraemia]
decreased urine output, edema, general malaise [renal dysfunction]
cold feeling, vomiting, loss of consciousness [shock, syncope, loss of consciousness]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
