部份中文依匹斯汀处方信息（仅供参考）
药品名称：阿司匹林兰索拉唑片
英文名称：TAKELDA
剂型及规格：
阿司匹林100mg /兰索拉唑15mg。
适应症：
本品用于预防心脏病发作，中风等心脑血管事件的发生，降低长期使用低剂量阿司匹林发生胃十二指肠溃疡的风险，主要用于心绞痛；心肌梗塞等。
阿司匹林自1977年首次被证实可预防治疗血栓以来，在全球超过300项大型随机临床研究结果奠定了阿司匹林在缺血性脑卒中和心血管事件防治中的基石地位。阿司匹林能与环加氧酶活性部分丝氨酸发生不可逆的乙酰化反应，使酶失活，抑制花生四烯酸代谢，减少对血小板有强大促聚集作用的血栓烷A2（TXA2）的产生，使血小板功能抑制。现已明确，阿司匹林对血小板功能亢进而引起血栓拴塞性疾病效果肯定。对急性心肌梗塞或不稳定性心绞痛患者，可降低再梗塞率及死亡率；对一过性脑缺血也可以减少发生率及死亡率。
由于阿司匹林对血小板聚集的作用，在血管疾病的防治中非常重要。近年来，随着冠心病发病率的日益增高。国内应用阿司匹林防治冠心病的病例也越来越多。常规剂量为50-300 mg/d。英国的两项多中心研究显示，服用阿司匹林300 mg/d所导致的出血性消化性溃疡的发生率3.9%,降低剂量后其危险性稍降低,即150mg/d,消化性溃疡的发生率为3.2%，75 mg/d为2.3%，提示阿司匹林有较高的消化性溃疡的发病率,且不存在所谓的“安全剂量”。
兰索拉唑为质子泵抑制剂(PPI)，作用于胃黏膜壁细胞泌酸过程的终末环节，降低壁细胞中的H-K-ATP酶的活性，从而减少基础胃酸、各种刺激引起的胃酸分泌和H2受体拮抗剂不能抑制的内二丁基环腺苷酸引的胃酸分泌。从而达到预防和迅速控制消化道黏膜损。研究结果表明，预防性地给予兰索拉唑能减少服用阿司匹林患者消化性溃疡的复发，本品值得在临床上应用。

TAKELDA Combination Tablets（タケルダ配合錠） 
Brand name : TAKELDA Combination Tablets
　Active ingredient: Aspirin Lansoprazole
　Dosage form: white to yellowish white tablet with redbrown to dark-brown flecks, diameter 10.0 mm, thickness 5.4 mm
　Print on wrapping: (face) タケルダ, 水でお飲みください (back) タケルダ, アスピリン・ランソプラゾール配合
Effects of this medicine
Aspirin inhibits activities of platelet cyclooxygenase-1 to suppress platelet aggregation and eventually delay or prevent blood coagulation while lansoprazole inhibits the enzymatic activity of proton pump in the gastric mucosa to suppress gastric acid secretion.
Aspirin prevents obstruction of a blood vessel by a blood clot that has formed but may cause gastric or duodenal ulcers; therefore, lansoprazole prevents such untoward events.
It is usually used to suppress thrombus/embolus formation due to angina pectoris, myocardial infarction, or ischemic cerebrovascular disorder or to suppress thrombus/embolus formation after coronary artery bypass grafting (CABG) or percutaneous transluminal coronary angioplasty (PTCA) in patients with a history of gastric or duodenal ulcers.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have peptic ulcer, hematological disorder or a history of hematological disorder, bleeding tendency or predisposition to bleeding tendency, bronchial asthma or a history of bronchial asthma, liver disorder or a history of liver disorder, renal disorder or a history of renal disorder.
If you drink alcohol on a regular basis.
If you are scheduled for surgery, cardiac catheter test or tooth extraction.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•For adults: In general, take 1 tablet at a time, once a day. Strictly follow the instructions.
•This medicine cannot be dissolved in the mouth. Take the medicine with water without chewing or breaking it into pieces.
•If you miss a dose, take the missed dose as soon as possible. You should never take two doses at one time.
•If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
•Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
•This medicine may induce or enhance gastrointestinal bleeding; therefore, avoid taking this medicine with any alcoholic beverage.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include constipation, diarrhea, rash, itching, polymorphic erythema, swelling, anemia, platelet hypofunction (prolonged bleeding time), enlarged feeling of abdomen, stomatitis, colitis, headache, dizziness, excitement, conjunctivitis, gynecomastia, malaise, over breathing, and hypoglycemia. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•generalized rash, facial swelling, breathlessness [anaphylaxis, shock]
•dullness, fever, shortness of breath, nasal bleeding/subcutaneous hemorrhage, red-brown urine [pancytopenia, agarnulocytosis, aplastic anemia, granulocytopenia, hemolytic anemia, decreased platelet count, anemia]
•yellowing of the skin or whites of the eyes, dullness, loss of appetite [serous liver dysfunction]
•fever, general malaise, eruptions on/reddening of the skin and eyes and eruptions/reddening in the mouth, exfoliation of skin [toxic epidermal necrolysis, mucocutaneous-ocular syndrome, exfoliative dermatitis]
•fever, dry cough, breathlessness [interstitial pneumonia]
•fever, skin eruption, joint pain [interstitial nephritis]
•headache, nausea/vomiting, disturbance of consciousness, motor paralysis, bloody phlegm, bloody stool, nose bleeding, vision disorder [intracranial bleeding, pulmonary hemorrhage, gastrointestinal hemorrhage, epistaxis, ocular fundus bleeding]
•breathlessness, whistling sound [asthmatic attack]
•heartburn, heavy feeling of stomach, back pain, abdominal pain, diarrhea, bloody stool [peptic ulcer, small/large intestine ulcer]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
•Discard the remainder. Do not store them.
Takeda Chemical Industries, Ltd.Internal
Published: 6/2014
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.