Description
This medicine is a combination preparation of an angiotensin receptor blocker and a calcium antagonist. It lowers blood pressure by suppressing the vasoconstriction action of angiotensin II in vascular smooth muscles with angiotensin receptor blocker, and by dilating blood vessels with calcium antagonist.
It is usually used in the treatment of hypertension.
Presentation
Feature
One surface white, one surface white to yellowish white tablet (major axis: 14.2 mm, minor axis: 6.7 mm, thickness: approx. 5.3 mm)
Active Ingredients
Olmesartan medoxomil Azelnidipine
Effect/Efficacy
This medicine is a combination preparation of an angiotensin receptor blocker and a calcium antagonist. It lowers blood pressure by suppressing the vasoconstriction action of angiotensin II in vascular smooth muscles with angiotensin receptor blocker, and by dilating blood vessels with calcium antagonist.
It is usually used in the treatment of hypertension.
Usage/Dosage
In general, for adults, take 1 tablet at a time, once a day after breakfast. Strictly follow the instructions.
The medicine contains 10 mg of olmesartan medoxomil and 8 mg of azelnidipine in 1 tablet.
If you miss a dose, take the missed dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
Do not stop taking this medicine unless your doctor instructs you to do so.
Cautions
Precautions while taking this medicine
The medicine may cause dizziness or lightheadedness by decreasing blood pressure. Pay close attention when you work at heights, drive a car or operate dangerous machinery.
Do not drink grapefruit juice while you take the medicine because it may cause an excessive hypotensive response by increasing blood level of the medicine.
Contraindication
The most commonly reported adverse reactions include urticaria, rash, itch, dizziness and headache. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
- breathing difficulty, swelling in the eyelids/lips/tongue, urticaria [angioedema]
- decreased urine output, edema, headache [renal failure]
- numbness in the limbs and lips, muscular weakness, paralysis in the limbs [hyperkalemia]
- cold feeling, vomiting, loss of consciousness [shock, faint, loss of consciousness]
- general malaise, anorexia, yellowing in the skin/white of eyes [hepatic dysfunction, jaundice]
- nasal bleeding, gums bleeding, subcutaneous bleeding [thrombocytopenia]
- cold sweat, hungry feeling, lassitude [hypoglycemia]
- dizziness, lightheadedness [atrioventricular block, sinus arrest, bradycardia]
- muscle pain, losing strength, red-brown urine [rhabdomyolysis]
- itch, general redness, blood pressure falling, breathing diffichlty [anaphylaxis]
- mud-like or water-like stool, weight loss [severe diarrhea]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
