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药品英文名


Mexazolam


 药品别名


甲恶二氮卓、甲氯唑仑、Melex、Mexazolamum


 药物剂型


片剂：0.5mg，1mg。


 药理作用


本品为抗焦虑药。其抗焦虑作用、镇定作用及抗痉挛作用均比地西泮强，并具有松弛肌肉作用。本品毒性较低，对慢性胃炎、高血压、心脏神经官能症的有效率分别为85.7%，75.0%，72.7%。对恐惧症、抑郁症、强迫症及睡眠障碍等精神症状有明显改善作用。


 药动学


口服吸收快，1～2h即达血药峰浓度，在肝脏代谢，最后经尿和粪便排出。


 适应证


主要用于不安、紧张、抑郁、强迫性障碍、恐怖及睡眠障碍等神经官能症；亦用于自主神经失调及身心疾病等。


 禁忌证


1.急性闭角型青光眼、重症肌无力及婴幼儿禁用。有心、肝、肾疾病，脑器质性疾病及老年人禁用。2.妊娠前3个月孕妇禁用。


 注意事项


1.肝、肾功能不全(或受损)时宜慎用，需调整剂量。2.其他：用药期间不宜饮酒，不宜开车或进行机器操作。


 不良反应


1.长期大量用药会产生依赖性，突然停药或急剧减量可出现戒断症状。2.偶可见口渴、食欲缺乏、消化不良、血压下降及转氨酶升高等不良反应。


 用法用量


口服：成人一般每次0.5～1.0mg，每天3次。老年人每天剂量为1.5mg。


 药物相应作用


中枢抑制药、吩噻嗪类药、巴比妥类药、单胺氧化酶抑制剂、酒精等均可增加本品作用，合用时注意调整剂量。

Description

This medicine acts on benzodiazepine receptors in the brain, and relieves anxiety and stress.
It is usually used for the treatment of anxiety, stress and depression in neurosis; fatigability; obsession, phobia and sleep disorder; and somatic symptoms in psychosomatic diseases (gastric and duodenal ulcer, etc.), anxiety, stress, depression, fatigability, and sleep disorder.

Presentation

100 tablets

Feature

white tablet

Active Ingredients

Mexazolam

Effect/Efficacy

This medicine acts on benzodiazepine receptors in the brain, and relieves anxiety and stress.
It is usually used for the treatment of anxiety, stress and depression in neurosis; fatigability; obsession, phobia and sleep disorder; and somatic symptoms in psychosomatic diseases (gastric and duodenal ulcer, etc.), anxiety, stress, depression, fatigability, and sleep disorder.

Usage/Dosage

General dosage regimen: For adults, take 1/2 to 1 tablet (0.5-1 mg of the active ingredient) at a time, 3 times daily. The dosage may be adjusted according to the diseases, age or symptoms. For the elderly, the daily dose is limited to 1.5 tablets. Strictly follow the instructions of your doctor/pharmacist.
Take a dose as soon as possible when you remembered that you missed a dose. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. DO NOT take a double dose to make up for the missed dose.
If you took too much of this medicine (more than ordered), check with your doctor/pharmacist.
Do not stop taking this medicine without the instructions of your doctor.

Cautions

If you ever experienced any allergic reaction (itch, rash etc.) to any medicine.
If you are patient with glaucoma or myasthenia gravis.
If you are pregnant or breastfeeding.
If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

This medicine may cause drowsiness; decline of attention, concentration or reflection. Avoid driving a car or operating dangerous machinery after taking this medicine.
Please note that drinking alcohol may enhance the effect of this medicine.

Keep out of the reach of children. Store away from direct sunlight and heat.
Discard the remainder. Do not store them.

Contraindication

Common side effects are reported as below. If any of them occurs, check with your doctor/pharmacist: drowsiness, lightheadedness, malaise, dizziness, somnolence, thirsty, rash, etc.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
being unable to stop taking the medicine despite trying to stop it [dependence]
being disturbed and unable to have normal thoughts, disoriented to time or place, to see or hear things which do not exsit [irritable excitation, confusion]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.