Description
This medicine lowers blood pressure by reducing peripheral vascular resistance via antagonism against receptor for the pressor substance angiotensin II as well as via its action upon the calcium channel in the vascular smooth muscle.
It is usually used for treatment of hypertension.
Presentation
20tablets
Feature
Light red oval tablets
Active Ingredients
Candesartan cilexetil, amlodipine besilate
Effect/Efficacy
This medicine lowers blood pressure by reducing peripheral vascular resistance via antagonism against receptor for the pressor substance angiotensin II as well as via its action upon the calcium channel in the vascular smooth muscle.
It is usually used for treatment of hypertension.
Usage/Dosage
○ General dosage is as follows.
● For adults, take 1 tablet at a time, once a day. Strictly follow the instructions.
○ If you miss a dose, take the missed dose as soon as possible. If it is less than 8 hours to the next dose, skip the missed dose and then continue your regular dosing schedule. You should never take two doses at one time.
○ If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
○ Do not stop taking this medicine unless your doctor instructs you to do so.
Cautions
Precautions while taking this medicine：
As dizziness and light-headedness may appear due to excessive lowering of blood pressure, take extra care when working at heights or operating dangerous machinery such as driving a car.
Do not take the medicine together with grapefruits juice.
Contraindication
● The most commonly reported adverse reactions are following symptoms. If any of these symptoms occur, consult with your doctor or pharmacist.
- rash, itching, photosensitivity, angiitis, dizziness, light-headedness, dizziness on standing up, glow, fall in blood pressure, abdominal discomfort, enlarged feeling of the abdomen, diarrhea, cough, ear ringing, hives and erythema multiforme
● The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
- swelling of face, tongue and throat, breathlessness, feeling cold, vomiting, loss of consciousness [angioedema, shock, syncope, loss of consciousness]
- decreased urinary output, swelling of face and hands/feet, fever, lassitude, muscle pain, brown urine [acute renal failure, rhabdomyolysis]
- numbness of hands/feet and lips, muscle weakness [hyperkalemia]
- yellowing of the skin or whites of the eyes, dullness, loss of appetite [liver dysfunction, jaundice, fulminant hepatitis]
- fever, sore throat, dullness, nose bleeding, gingival bleeding, subcutaneous bleeding [agranulocytosis, decreased white blood cell count, decreased platelet count]
- fever, dry cough, breathlessness [interstitial pneumonia]
- cold sweat, feeling hungry, tremor in hands [hypoglycemia]
- bradycardia, dizziness [atrioventricular block]
Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
