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· 【药品名称】
通用名称：阿昔洛韦颗粒剂
英文名称：Acyclovir Granules
拼音名称：

· 【成份】阿昔洛韦

· 【性状】白色或类白色可溶颗粒，无臭，味微甜。

· 【规格】 0.5g

· 【用法用量】口服。成人一次1袋（0.2g），一日5次（白天每4小时1次）。一疗程5～10日。或遵医嘱。

· 【不良反应】偶有头晕、头痛、关节痛、恶心、呕吐、腹泻、胃部不适、食欲不振、口渴、白细胞下降、蛋白尿及尿素氮轻度升高等。

· 【禁忌】对本品过敏者和孕妇禁用。

· 【注意事项】
肾功能不全者、小儿及哺乳期妇女遵医嘱慎用。服药期间宜多饮水。

· 【药理毒理】核苷类抗病毒药，本品能被病毒的胸腺嘧啶核苷激酶选择性地磷酸化，从而转化为单磷酸酯，后者受细胞酶的作用，再转化为二磷酸酯和三磷酸酯。阿昔洛韦三磷酸酯可干扰DNA的聚合酶，特别是能干扰疱疹病毒DNA酶，从而抑制病毒DNA的复制。

· 【贮藏】密封保存。

Description

This medicine suppresses the proliferation of herpes simplex and varicella/herpes zoster viruses.
It is usually used to suppress the onset of herpes simplex, herpes simplex virus infection (herpes simplex) associated with hematopoietic stem cell transplantation, or to suppress the recurrence of herpes zoster, varicella or genital herpes.

Presentation

0.5g x 100 bags

Feature

Active Ingredients

Aciclovir　400mg/1g, 200mg/0.5g

Effect/Efficacy

This medicine suppresses the proliferation of herpes simplex and varicella/herpes zoster viruses.
It is usually used to suppress the onset of herpes simplex, herpes simplex virus infection (herpes simplex) associated with hematopoietic stem cell transplantation, or to suppress the recurrence of herpes zoster, varicella or genital herpes.

Usage/Dosage

For herpes simplex: In general, for adults, take 0.5 g (200 mg of the active ingredient) at a time, 5 times a day. For children, take 0.05 g (20 mg) per kilogram of the body weight at a time, 4 times a day. However, the maximum single dose is 0.5 g (200 mg).
For suppression of onset of herpes simplex virus infection (herpes simplex) associated with hematopoietic stem cell transplantation: In general, for adults, take 0.5 g (200 mg of the active ingredient) at a time, 5 times a day from 7 days prior to hematopoietic stem cell transplantation to 35 days after transplantation throughout. For children, take 0.05 g (20 mg) per kilogram of the body weight at a time, 4 times a day from 7 days prior to hematopoietic stem cell transplantation to 35 days after transplantation throughout. However, the maximum single dose is 0.5 g (200 mg).
For herpes zoster : In general, for adults, take 2 g (800 mg of the active ingredient) at a time, 5 times a day. For children, take 0.05 g (20 mg) per kilogram of the body weight at a time, 4 times a day. However, the maximum single dose is 2 g (800 mg).
For varicella : In general, for children, take 0.05 g (20 mg of the active ingredient) per kilogram of the body weight at a time, 4 times a day. However, the maximum single dose is 2 g (800 mg).
For suppression of recurrence of genital herpes : In general, for children, take 0.05 g (20 mg of the active ingredient) per kilogram of the body weight at a time, 4 times a day. However, the maximum single dose is 0.5 g (200 mg).
In any case, the dosage may be adjusted according to the disease, age or symptoms. Strictly follow the instructions.
In general, take the medicine 5 times a day (after breakfast, after lunch, at around 4 pm, after dinner and before bedtime). In general, for children, take the medicine 4 times a day (after breakfast, after lunch, at around 4 pm and after dinner).
If you miss a dose, take the missed dose when you remember. However, if it is almost time for the next dose, skip the missed dose and follow your next dosing schedule. You should never take two doses at one time.
If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
Do not stop taking this medicine unless your doctor instructs you to do so.

Cautions

This medicine may cause dehydration. Take an appropriate amount of water while you are on this medicine. However, if you have been instructed to restrict fluid intake, please consult with your doctor or pharmacist.
This medicine may cause consciousness disorder. Pay attention when operating dangerous machinery, such as driving a car. Patients with renal dysfunction are more susceptible to consciousness disorder, so avoid operating dangerous machinery if instructed to do so by your doctor.

Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
Discard the remainder. Do not store them.

Contraindication

The most commonly reported adverse reactions include fever, rash, blister, erythema, hives, itch, fixed drug eruption, photosensitivity, abdominal pain, diarrhea, anemia and headache. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
respiratory distress, angioedema, generalized flushing [anaphylaxis shock, anaphylaxis]
decreased urine output, edema, headache [acute renal failure]
consciousness disorder (coma), hallucination, convulsion [neuropsychiatric symptom]
fever, bloodshot eyes, mucosal eruption with pain in the oral mucosa [toxic epidermal necrolysis, mucocutaneous ocular syndrome]
general malaise, loss of appetite, yellow discoloration of the skin and the white of eyes [hepatitis, liver dysfunction, jaundice]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.