Astellas Pharma公司的Suglat（伊格列净/L-脯氨酸，ipragliflozin L-proline)25和50mg片剂治疗2型糖尿病在日本获得上市许可证。该公司于2013年3月申报此批准。

伊格列净/L-脯氨酸属于选择性钠/钠-葡萄糖转运蛋白质类2(SGLT2)抑制剂，是与Kotobuki Pharmaceutical公司通过科研合作发现和开发的。该药通过选择性抑SGLT2而抑制葡萄糖再摄取，从而降低血糖。

伊格列净 L-脯氨酸单药治疗的一项III期关键性试验，以及该药与其他降糖药联用的多项临床研究，支持了本品在日本的获批。Astellas公司将制造和销售产品，并与Kotobuki Pharmaceutical和MSD K.K.两家公司共同推广.

This medicine inhibits SGLT2 which resorbs glucose in the kidney, thus reducing blood glucose through the excretion of excess glucose into urine.
It is usually used for the treatment of type 2 diabetes.

Ipragliflozin L-Proline

In general, for adults, take 1 tablet (50 mg of ipragliflozin) at a time, once a day before or after breakfast. If the effect of this medicine is insufficient, it may be increased up to 2 tablets (100 mg) once a day while carefully following the course of the disease. If you have a severe hepatic impairment, the dosage may be started with low doses. Strictly follow the instructions.
If you miss a dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
Do not stop taking this medicine unless your doctor instructs you to do so.

Strictly follow the instructions on dietary/exercise therapy.
This medicine may cause hypoglycemic symptoms. Be aware of operating in potentially hazardous activities such as driving a car and working at heights.
Take foods containing sugar or drink juice if any hypoglycemic symptoms occur. If you are taking in conjunction with α-glucosidase inhibitors (medicines which delay the uptake of glucose) and hypoglycemic symptoms develop, you must take in glucose.
Take a larger amount of water, since this medicine may cause dehydration. Intake of water or tea is desirable, since drink including sugar such as isotonic drink may increase blood glucose.
Do not stop taking water or decrease the amount of water on your own judgment.
Stop taking the medicine if you have repeated diarrhea/vomiting or cannot take food or water continuously due to decreased appetite.

Possible adverse reactions to this medicine
The most commonly reported adverse reactions include urinary frequency, thirst, constipation, and weight loss. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
light headedness, lassitude, sweating, hunger, shaking of hands and feet [hypoglycemia]
chills, fever, flank pain, back pain, lower back pain [pyelonephritis]
Thirst/dry mouth, large urinary volume, dizziness/lightheadedness [dehydration]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.