Amenalief 阿米那韦薄膜片
通用名称阿米那韦薄膜片
Amenamevir
品牌名称Amenalief
アメンリーフ
产地|公司日本(Japan) |
Maruho(Maruho)
技术状态原研产品
成分|含量200mg
包装|存储14片/盒
室温
微信客服
Xirou_Canada
微信ID
(8:00-15:00)
服务时间
使用说明书
（免责声明：本说明书仅供参考，不作为治疗的依据，不可取代任何医生、药剂师等专业性的指导。本站不提供治疗建议，药物是否适合您，请专业医生（或药剂师）决定。）
等待内容更新
中文说明
（免责声明：本说明书仅供参考，不作为治疗的依据，不可取代任何医生、药剂师等专业性的指导。本站不提供治疗建议，药物是否适合您，请专业医生（或药剂师）决定。）
药物分类名称
抗疱疹病毒剂
批准日期：2017年8月
商標名
Amenalief Tab
一般名
アメナメビル(Amenamevir)(JAN)
化学名
N-(2, 6-Dimethylphenyl)-N-(2-｛[4-(1, 2, 4-oxadiazol-3-yl)phenyl]amino｝-2-oxoethyl)-1, 1-dioxothiane-4-carboxamide
分子式
C24H26N4O5S
分子量
482.55
構造式
性状
白色至微黄色白色或浅棕白色晶体或粉末。
易溶于二甲基亚砜，微溶于乙腈，难溶于甲醇或乙醇（99.5），难溶于水。
熔点
约217°C（分解）
分配系数
Log P（1-辛醇/水）= 2.0
批准条件
制定药品风险管理计划并适当实施。
药效药理
1.抗病毒作用
对水痘带状疱疹病毒的抗病毒作用指示（在培养的细胞中病毒生长抑制），16中的EC50值为0.038〜0.10μmol/L）。此外，保持抗病毒活性对水痘带状疱疹病毒的阿昔洛韦低敏感菌株，交叉抗性观察到16）。
2.作用机制
Amenamebiru是，疱疹病毒的解旋酶-引发酶复合体的DNA依赖性ATPase活性，通过抑制解旋酶活性和引发酶的活性，抑制DNA复制疱疹病毒。单纯疱疹病毒1型解旋酶引发酶复合物的DNA依赖性ATPase活性，解旋酶活性和引发酶的活性，分别0.078μmol/L（50％抑制浓度），0.1微摩尔/L和0.03μmol/L或更16，在一个浓度抑制）。也抑制DNA在至少0.03μmol/ L的浓度复制水痘带状疱疹病毒
适应症
帯状疱疹
用法与用量
成人，每天一次400毫克作为阿米那韦，在饭后每天口服一次
外文说明
（免责声明：本说明书仅供参考，不作为治疗的依据，不可取代任何医生、药剂师等专业性的指导。本站不提供治疗建议，药物是否适合您，请专业医生（或药剂师）决定。）
Description
This medicine suppresses the proliferation of virus causing herpes zoster.
It is usually used to treat herpes zoster.
Presentation
14 tablets
Feature
pale yellow tablet,
minor axis: 7.9 mm, major axis: 15.0 mm, thickness: 5.7 mm
Active Ingredients
Amenamevir 200mg
Effect/Efficacy
This medicine suppresses the proliferation of virus causing herpes zoster.
It is usually used to treat herpes zoster.
Usage/Dosage
In general, for adults, take 2 tablets (400 mg of the active ingredient) at a time, once a day after a meal. Strictly follow the instructions.
If you miss a dose, take the missed dose as soon as possible. However, if it is almost time for the next dose, skip the missed dose and follow your regular dosing schedule. Do not take two doses at one time in order to make up for a missed dose.
If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
Do not stop taking this medicine unless your doctor instructs you to do so.
Cautions
If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you are pregnant or breastfeeding.
If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Grapefruit juice may increase the blood level of the medicine and intensify medicinal effects. Health food containing St. John's wort may decrease the blood level of the medicine and diminish medicinal effects. Avoid taking these foods and drinks.
Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
Discard any unused leftover amount. Do not keep it.
Contraindication
The reported adverse reactions include drug eruption (erythema, eczema, rash, etc.), diarrhea, gastritis, nausea, hypertension, periodontitis and tooth abscess. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
No pertinent entries.
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
