【药品名称】

商品名称：DC Bead
通用名称：栓塞微球
英文名称：Drug Delivery Embolisation System

【成份】

该产品是以聚乙烯醇(PVA)为主链的大分子交联聚合体，以聚乙烯醇(PVC)主链为骨架，以共价键型式和交联剂、活性蓝连接而成。保存溶液为生理缓冲溶液。蒸汽灭菌，一次性使用。

【 适应症 】

该产品用于富血管恶性肿瘤供血血管的栓塞。

DC Bead™正快速成为治疗中晚期肝癌的首选产品。这是一个药物洗脱栓塞系统, 提供 intra-arterially, 并结合了物理闭塞的血液供应的影响, 一个肿瘤与当地控制交付化疗药物。虽然不适合与所有药物使用, 该设备的组成部分, 使快速加载和持续洗脱的治疗量的一系列临床相关的抗癌化合物。广泛的临床前测试证明了该装置的重现性和可靠性, 同时减少了系统性药物暴露和持续的局部药物传递。此外, 这些属性正在转化为临床肿瘤患者的重要好处。

The DC Bead™ is fast becoming the product of choice for use in the treatment of intermediate-stage hepatocellular carcinoma. It is a drug-eluting embolization system that is delivered intra-arterially and combines the effects of physical occlusion of the blood supply to a tumor with the local controlled delivery of a chemotherapeutic agent. While not suitable for use with all drugs, the components of this device enable rapid loading and sustained elution of therapeutic amounts of a range of clinically relevant anticancer compounds. Extensive preclinical testing has demonstrated the reproducibility and reliability of the device, together with reduced systemic drug exposure and sustained local drug delivery. Moreover, these attributes are translating into the clinic as significant benefits to patients with many types of liver tumors. 

载药洗脱微球结合了栓塞与局部化疗的优势,其经微导管注射,选择性对肿瘤供血动脉进行栓塞,使肿瘤缺血坏死;同时其向病灶部位持久缓慢地释放药物,形成局部高浓度,对肿瘤细胞产生显著的细胞毒效应。近年来载药DC Bead 用于肝癌的栓塞化疗研究取得了较快的发展。