简介：

冷链产品（储存在2-8度）。

部份中文普来纳西处方资料（仅供参考）
英文药名: Plenaxis（abarelix for injectable suspension）
中文药名:  普来纳西（阿巴瑞克注射混悬液）
生产厂家：Praecis制药
药品介绍
2003年11月25日，Praecis制药公司宣布，FDA已批准其开发的Plenaxis（abarelix注射用混悬液）上市，这是目前得到批准的第一种可存储的促性腺激素释放激素拮抗剂配方， Plenaxis是第一个促性腺素释放激素(GnRH)拮抗剂，为长效混悬剂配方。用于不适宜用LHRH激动剂治疗和拒绝手术切除的晚期症状性前列腺癌(PCA)，并具有一种以上下述3种情况即1)因转移而出现神经损伤的风险；2)因局部侵犯或转移病而出现的尿道或膀胱出口阻塞和3)因骨骼转移而出现的需要持续用麻醉镇痛药的严重骨痛的男性病人治标性治疗。

促性腺激素释放激素拮抗剂（Gonadotropin-releasing hormone antagonist） is a synthetic peptide that competes with the neurohormone GnRH for its receptor, thus decreasing or blocking GnRH action. As a result endogenous pituitary output of FSH and LH is shut down.
GnRH antagonists are also derivatives of the natural GnRH decapeptide with multiple amino acid substitutions. These substitutions modify the agent so that it blocks the receptor and decreases FSH and LH secretions within hours. In contrast to GnRH agonists, antagonists have no flare effect, thus their therapeutic effect is immediately apparent. However, their action is short-lived and daily injections are necessary to maintain their effect. Typically endogenous FSH and LH activity returns about 40 hours after cessation of GnRH antagonist administration, although with a higher dose the return to normal pituitary function will be postponed for longer. Unlike the GnRH agonists, long acting or depot forms of the agent are not currently available, thus GnRH antagonists are not used in the long term therapy of patients with cancer where hormone levels need to be kept low for a long time. As of 2006, Histrelin (as Supprelin-LA) is awaiting approval for use as a 12-month depot injection.
The main application of GnRH antagonists is currently short term use in the prevention of endogenous ovulation in patients who undergo exogenous stimulation with FSH in the preparation for IVF. Typically they are administered in the mid- to late follicular phase in stimulated cycles prior to the administration of hCG. Because they decrease luteal competence, patients are usually given some form of luteal support after egg retrieva l.
GnRH antagonists for long term use are under investigation (i.e. abarelix), their advantage over GnRH agonist would be that they lack the initial flare stimulation and induce quickly a hypogonadal situation.